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Human molecular genetics / Tom Strachan and Andrew P. Read.

Av: Medverkande: Språk: Engelska Utgivningsuppgift: Boca Raton, Florida : CRC Press, 2019Datum för upphovsrätt: ©2019Utgåva: Fifth editionBeskrivning: xiii, 770 sidor illustrationer 28 cmInnehållstyp:
  • text
  • still image
Medietyp:
  • unmediated
Bärartyp:
  • volume
ISBN:
  • 0815345895
  • 9780815345893
  • 0367002507
  • 9780367002503
Ämnen: DDK-klassifikation:
  • 611.01816 23/swe
Library of Congress (LC) klassifikationskod:
  • QH431
Annan klassifikation:
  • Vbba
Innehåll:
PART 1: Basics of DNA, Chromosomes, Cells, Development, and Inheritance -- 1. Basic Principles of Nucleic Acid Structure and Gene Expression -- 2. Fundamentals of Cells and Chromosomes -- 3. Fundamentals of Cell-Cell Interactions and Immune System Biology -- 4. Aspects of Early Mammalian Development, Cell Differentiation, and Stem Cells -- 5. Patterns of Inheritance -- PART 2: Understanding Genomes -- 6. Core DNA Technologies: Amplifying DNA, Nucleic Acid Hybirdization, and DNA Sequencing -- 7. Analyzing the Structure and Expression of Genes and Genomes -- 8. Principles of Genetic Manipulation of Mammalian Cells -- 9. Uncovering the Architecture and Workings of the Human Genome -- 10. Gene Regulation and the Epigenome -- PART 3: Genetic Variation Between Individuals and Species -- 11. An Overview of Human Genetic Variation -- 12. Human Population Genetics -- 13. Comparative Genomics and Genome Evolution -- 14. Human Evolution -- PART 4. Human Genetic Disease -- 15. Chromosomal Abnormalities and Structural Variants -- 16. Molecular Pathology: Connecting Phenotypes to Genotypes -- 17. Mapping and Identifying Genes for Monogenic Disorders -- 18. Complex Disease: Identifying Susceptibility Factors and Understanding Pathogenesis -- 19. Cancer Genetics and Genomics -- PART 5. Applied Human Molecular Genetics -- 20. Genetic Testing in Healthcare and The Law -- 21. Modeling Organisms and Modeling Disease -- 22. Genetic Approaches to Treating Disease
Sammanfattning: Human Molecular Genetics has been carefully crafted over successive editions to provide an authoritative introduction to the molecular aspects of human genetics, genomics and cell biology. Maintaining the features that have made previous editions so popular, this fifth edition has been completely updated in line with the latest developments in the field. Older technologies such as cloning and hybridization have been merged and summarized, coverage of newer DNA sequencing technologies has been expanded, and powerful new gene editing and single-cell genomics technologies have been added. The coverage of GWAS, functional genomics, stem cells, and disease modeling has been expanded. Greater focus is given to inheritance and variation in the context of populations and on the role of epigenetics in gene regulation.
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Exemplartyp Aktuellt bibliotek Placering Hyllsignatur Status Förfallodatum Streckkod Exemplarreservationer
Kurslitteratur Biblioteket HKR Biblioteket 611 Strachan Tillgänglig 11156000190174
Kurslitteratur Biblioteket HKR Biblioteket 611 Strachan Tillgänglig 11156000190176
Kurslitteratur Biblioteket HKR Biblioteket 611 Strachan Tillgänglig 11156000190178
Kurslitteratur Biblioteket HKR Biblioteket 611 Strachan Tillgänglig 11156000190179
Dagslån Biblioteket HKR Biblioteket 611 Strachan Tillgänglig 11156000190177
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Human Molecular Genetics has been carefully crafted over successive editions to provide an authoritative introduction to the molecular aspects of human genetics, genomics and cell biology.

Maintaining the features that have made previous editions so popular, this fifth edition has been completely updated in line with the latest developments in the field. Older technologies such as cloning and hybridization have been merged and summarized, coverage of newer DNA sequencing technologies has been expanded, and powerful new gene editing and single-cell genomics technologies have been added. The coverage of GWAS, functional genomics, stem cells, and disease modeling has been expanded. Greater focus is given to inheritance and variation in the context of populations and on the role of epigenetics in gene regulation.

Key features:

Fully integrated approach to the molecular aspects of human genetics, genomics, and cell biology Accessible text is supported and enhanced throughout by superb artwork illustrating the key concepts and mechanisms Summary boxes at the end of each chapter provide clear learning points Annotated further reading helps readers navigate the wealth of additional information in this complex subject and provides direction for further study Reorganized into five sections for improved access to related topics Also new to this edition - brand new chapter on evolution and anthropology from the authors of the highly acclaimed Human Evolutionary Genetics

A proven and popular textbook for upper-level undergraduates and graduate students, the new edition of Human Molecular Genetics remains the 'go-to' book for those studying human molecular genetics or genomics courses around the world.

Includes bibliographical references and index.

PART 1: Basics of DNA, Chromosomes, Cells, Development, and Inheritance -- 1. Basic Principles of Nucleic Acid Structure and Gene Expression -- 2. Fundamentals of Cells and Chromosomes -- 3. Fundamentals of Cell-Cell Interactions and Immune System Biology -- 4. Aspects of Early Mammalian Development, Cell Differentiation, and Stem Cells -- 5. Patterns of Inheritance -- PART 2: Understanding Genomes -- 6. Core DNA Technologies: Amplifying DNA, Nucleic Acid Hybirdization, and DNA Sequencing -- 7. Analyzing the Structure and Expression of Genes and Genomes -- 8. Principles of Genetic Manipulation of Mammalian Cells -- 9. Uncovering the Architecture and Workings of the Human Genome -- 10. Gene Regulation and the Epigenome -- PART 3: Genetic Variation Between Individuals and Species -- 11. An Overview of Human Genetic Variation -- 12. Human Population Genetics -- 13. Comparative Genomics and Genome Evolution -- 14. Human Evolution -- PART 4. Human Genetic Disease -- 15. Chromosomal Abnormalities and Structural Variants -- 16. Molecular Pathology: Connecting Phenotypes to Genotypes -- 17. Mapping and Identifying Genes for Monogenic Disorders -- 18. Complex Disease: Identifying Susceptibility Factors and Understanding Pathogenesis -- 19. Cancer Genetics and Genomics -- PART 5. Applied Human Molecular Genetics -- 20. Genetic Testing in Healthcare and The Law -- 21. Modeling Organisms and Modeling Disease -- 22. Genetic Approaches to Treating Disease

Human Molecular Genetics has been carefully crafted over successive editions to provide an authoritative introduction to the molecular aspects of human genetics, genomics and cell biology. Maintaining the features that have made previous editions so popular, this fifth edition has been completely updated in line with the latest developments in the field. Older technologies such as cloning and hybridization have been merged and summarized, coverage of newer DNA sequencing technologies has been expanded, and powerful new gene editing and single-cell genomics technologies have been added. The coverage of GWAS, functional genomics, stem cells, and disease modeling has been expanded. Greater focus is given to inheritance and variation in the context of populations and on the role of epigenetics in gene regulation.

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